IDH2 and acute myeloid leukemia: The discovery that some AML blasts and glioma cells carry specific mutations in isocitrate dehydrogenase isoform 1 (IDH1) and 2 (IDH2), resulting in the generation of a particular metabolite — the (R)-enantiomer of 2-hydroxyglutarate ((R)-2HG), led to development of small molecular inhibitors which effectively inhibit 2HG production; effectively targeting the aberrant metabolism of AML blasts (10).