The ongoing IDHENTIFY (ClinicalTrials.gov, NCT02577406) international, multicenter, phase 3 randomized, open-label trial is ongoing to compare the efficacy of enasidenib to conventional care (including best supportive care only, azacitidine subcutaneously plus best supportive care, low-dose cytarabine subcutaneously plus best supportive care, or intermediate-dose cytarabine intravenously plus best supportive care) in 319 patients, older than 60years, with advanced R/R IDH2-mutated AML. This evidence concerns the gene IDH2 and acute myeloid leukemia.