FLT3 and acute leukemia: In mice, mIDH2R140Q in hematopoietic tissues was not sufficient for the development pf AML phenoype, suggesting the requirement of additional driver mutations, like overexpression of HoxA9 and Meis1a or mutations in FMS-like tyrosine kinase 3 (FLT3) to drive acute leukemia in vivo (30).