HSP90B1 and colonic neoplasm: Strikingly, they also discovered that deletion of GRP94 in macrophages attenuated colon tumor initiation, which was correlated with reduced mutation rates of β-catenin, reduced activation of the canonical Wnt signaling, and increased efficiency of the DNA repair machinery as well as reduced expression of pro-inflammatory cytokines, including IL-17 and IL-23 in the tumor microenvironment (23).