COL2A1 and acute myeloid leukemia: In order to fully elucidate the mechanism of the hub prognostic ceRNA network in AML, and at the same time look for the potential way for TME to determine the fate of AML, we performed Pearson test on the correlation between EPB41L3, COL2A1, CYP1B1-AS1, C9orf106 and TME immune cells and plotted heatmap (Figure 8A).