However, except for the association of the same features (nonparallel orientation growth, main posterior shadowing, microcalcification, larger tumor size, and HER-2 gene overexpression) with ALN metastasis, the PTFM nomogram incorporated more US features of primary breast tumors, such as multiple tumors, irregular tumors, and abundant blood supply. The gene discussed is ERBB2; the disease is breast neoplasm.