Moreover, our single‐cell analysis identified specific genes enriched for CRC CSCs, including PROX1, TNFRSF19/TROY, SMOC2, NOTUM, BAMBI, PHLDA1, IFI27, and ERBB3, and these genes were expressed at remarkably higher levels in CSCs distinct from any other cell type (Figure 1i). Here, SMOC2 is linked to colorectal carcinoma.