Six up‐regulated genes (EPCAM, CDH1, KRT18, CLDN4, CXADR, and SLC12A2) selected based on our functional analysis above and shared by both CSCs and EPCs in SMART‐seq2 and 10 × Genomics data, predicted the poorest survival rate of CRC patients (P = 1.686 × 10−5, Figure S6b right, Supporting Information). Here, CLDN4 is linked to colorectal carcinoma.