These pathways play a key role in maintaining the stemness and undifferentiated state of CSCs in CRC, such as epithelial–mesenchymal transition (EMT) linked to cancer progression and metastasis.[25, 28] Ligand CTNNB1 (β‐CATENIN), effectors LEF1 and TCF7L2, WNT targets AXIN2 and MMP7, WNT receptors such as LRP5, LRP6, FZD1, FZD3, and FZD6 were highly expressed in CSCs (Figure 1g). The gene discussed is LEF1; the disease is cancer.