The cellular plasticity has been reported in healthy intestine[28, 55] and the stem cell plasticity is tightly linked to changes in WNT levels,[56] while cancer cells also can dynamically shift between a differentiated and a stem‐like state.[1c] Even the LGR5 negative cells possess the intrinsic capacity for rebuilding the epithelial hierarchy organization.[57] CSCs are often embedded in and thus confused with EPCs.[57a] Here, we found that quiescent CSCs also exhibit high plasticity and can generate EPCs. The gene discussed is LGR5; the disease is cancer.