AKT1 and lung cancer: KRT18 (cytokeratin 18, also named CK18) encodes for the type I intermediate filament chain keratin 18, and regulation of KRT18 by WNT is involved in AKT activation.[40] In addition, KRT18 plays an important role in chemo‐sensitivity in lung cancer.[41]KRT18 was highly expressed in the tumor site as assessed by both RT‐qPCR and immunofluorescence (Figure S6d,e, Supporting Information).