TCF7L2 and cancer: These pathways play a key role in maintaining the stemness and undifferentiated state of CSCs in CRC, such as epithelial–mesenchymal transition (EMT) linked to cancer progression and metastasis.[25, 28] Ligand CTNNB1 (β‐CATENIN), effectors LEF1 and TCF7L2, WNT targets AXIN2 and MMP7, WNT receptors such as LRP5, LRP6, FZD1, FZD3, and FZD6 were highly expressed in CSCs (Figure 1g).