AIFM1 and neoplasm: As shown in Figure 7G and Figure S8A (Supporting Information), the depletion of DCAF10 showed no effect on the tumor suppressive role of the K244R mutant (comparing K244R&shDCAF10 to K244R), which is consistent with our proposed model that the K244R mutant of AIF triggers apoptosis via compromising OXPHOS.