OTUD1 and esophageal squamous cell carcinoma: We next performed immunohistochemical (IHC) staining of OTUD1 in 122 ESCC samples and found that low OTUD1 expression in ESCC patients significantly correlated with poor prognosis (Figure 1F; Figure S1C,D, Supporting Information), which further supported our speculation that low OTUD1 expression contributes to the chemoresistance and poor prognosis of ESCC patients.