However, the depletion of DCAF10 rescued the tumor suppression of ectopic OTUD1 expression in K244R mutant cells (comparing K244R&D1&shDCAF10 to K244R&D1), which is due to the inhibition of the MCL1 downregulation‐induced caspase‐dependent apoptosis pathway and AIF release (parthanatos). The gene discussed is OTUD1; the disease is neoplasm.