modified the tumor environment with laser irradiation.[106] They reported that by inducing mild hyperthermia in the tumor region with PTT, the chondroitin sulfate proteoglycan‐4 (CSPG4)‐specific CAR‐TCs were recruited in the tumor tissue and their proliferation and cytokine production was increased (Figure 12a). The gene discussed is CSPG4; the disease is neoplasm.