CD4 and neoplasm: After receiving 2 doses of the NPs 1 week apart, it was observed that the tumor volume in mice receiving the NPs was significantly reduced compared to those receiving free PTX.Combined radiotherapy and chemotherapy had a synergistic antitumor effect, resulting in an intense antitumor effect and even complete tumor remission in two of the subjects.[125] In another study, the membrane of natural CD4+ helper TCs was coated on PLGA NPsʼ core for trapping and neutralizing the human immunodeficiency virus (HIV) (Figure 21a).