It was revealed that the NK‐NPs (Figure 22b) maintain the protein composition of the parent NKCs on their surface, specifically those with key roles in tumor targeting (DNAX accessory molecule‐1 (DNAM‐1) and NKG‐2D) and M1 Mφ polarization (immunity‐related GTPase family M member 1 (IRGM1), cannabinoid receptor 1 (CB1), galectin‐12, RAB10, and receptor activator of nuclear factor kappa‐Β ligand (RANKL)) to cope with the immunosuppressive environment of the tumor tissue. This evidence concerns the gene CD226 and neoplasm.