Few other Nrf2 activators have also shown promising therapeutics against hyperglycemia and ED as demonstrated by Wang et al. Cinnamaldehyde, an Nrf2 activator, preserved nitric oxide (NO) levels and upregulated Nrf2 levels and its downstream regulations in the HUVEC cells and mouse aortas in the hyperglycaemic environment [63]. Here, NFE2L2 is linked to Hyperglycemia.