Studies focusing on biological roles of miRNAs after CAT clearly show their involvement in the regulation of the function of T-cells (including activation, energetic metabolism, response to antigen, etc.), dendritic cells (affecting their ability to present antigens and their maturation), endothelial cells (affecting their function and permeability), cardiomyocytes (affecting, e.g., their function and apoptosis) and potentially all other cell types involved in the complex process of cardiac allograft tolerance and rejection, including ACR, AMR, MR or CAV. Here, CAT is linked to miotic rate.