NQO1 and non-small cell lung carcinoma: For this purpose we selected the non-small cell lung carcinoma NCI-H460 cell line, with high endogenous levels of the nitroreductase DT-diaphorase 32 and increased levels of hypoxia in comparison to MDA-MB-231 (hypoxic fractions of 13.6% and 4.7% respectively 33, 34).