AKT1 and hepatocellular carcinoma: Moreover, the Akt activator SC79 restored the cell viability suppressed by the combination of sorafenib and 3-HAA while the Akt inhibitor MK2206 further decreased the cell viability (Fig. 3H & S3C), suggesting that 3-HAA induces apoptosis of sorafenib-resistant HCC cells via inhibiting Akt activity.