DSC2 and Arrhythmogenic right ventricular dysplasia: We then measured plasma sC5b9 levels in ARVC patients with different genotypes, including 17 patients with a mutation in PKP2, 12 patients with a mutation in DSG2, 3 patients with a mutation in DSP, 3 patients with a mutation in DSC2, and 1 patient with a mutation in JUP. Two out of the 87 ARVC patients (2.3%) had a mutation in the DES gene (DES p.R406W, DES p.R127C).