Interestingly, however, mutations in a growing number of nondesmosomal genes have also been reported in patients with ARVC, including genes associated with other cardiomyopathies and arrhythmia syndromes such as desmin (DES), titin (TTN), lamin A/C (LMNA), Phospholamban (PLN), Transmembrane Protein 43 (TMEM43), and the sodium channel Nav1.5 (SCN5A) 17, 43. Here, TMEM43 is linked to cardiomyopathy.