PFKFB3 and cancer: Inhibition of glycolysis enzyme, such as hexokinase 2 (HK2) 11-13, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 (PFKFB3) 14 and pyruvate kinase M2 (PKM2) 15, results in reduced cancer cell invasion and metastasis, indicating the critical role of glycolysis in these biological events.