PFKM and hepatocellular carcinoma: Re-expression of either ZEB1 or endogenous level-comparable PFKM completely rescued the decrease of glucose uptake and lactate production as well as ECAR and OCR levels in ZEB1 KD MHCC-97H (Figure 2B-D, 2H-I) and HCC-LM3 cells (Figure S1A-C).