Excessive leptin and leptin signaling activation leads to gastric tumors by inhibiting suppressors of cytokine signaling 3 in gastrointestinal epithelial cells 22 as well as increased expression of ectopic molecules related to intestinal epithelium, such as intestinal mucin 2 and Paneth cell marker PLA2, as well as decreased expression of the transcription factor SRY-box transcription factor 2 and H+/K+ ATPase 23. This evidence concerns the gene LEP and gastric neoplasm.