FLT3 and neoplasm: Moreover, spleens isolated from the SsD-treated group weighed less compared to those from control groups, indicating that SsD treatment markedly reversed the splenomegaly and suppressed the metastatic tumor cells in the spleen (C1498 mice: vehicle, 713 ± 62 mg; 0.1 mg/kg, 580 ± 51 mg; 0.5 mg/kg, 424 ± 34 mg; FLT3+ mice: vehicle, 691 ± 68 mg; 0.1 mg/kg, 581 ± 104 mg; 0.5 mg/kg, 457 ± 91 mg) (Figure 5C and 5E).