AKT1 and cancer: SsD, an effective component of Radix Bupleuri, exhibits a promising anti-tumor effect in various types of cancer, including lung cancer, liver cancer, breast cancer, prostate cancer, etc. Recently, we reported that SsD-loaded by a nanocomposite effectively inhibited tumor growth and metastasis of breast cancer in vitro and in vivo through VEGFR, AKT, and ERK related to the angiogenic pathway 34.