SsD, an effective component of Radix Bupleuri, exhibits a promising anti-tumor effect in various types of cancer, including lung cancer, liver cancer, breast cancer, prostate cancer, etc. Recently, we reported that SsD-loaded by a nanocomposite effectively inhibited tumor growth and metastasis of breast cancer in vitro and in vivo through VEGFR, AKT, and ERK related to the angiogenic pathway 34. This evidence concerns the gene KDR and breast cancer.