To explore the biological function of MYBL2 and investigate whether it plays a positive role in CRPC progression, we established LNCaP and MDA PCa 2b, stably expressing MYBL2, as well as LNCaP-AI and PC-3 cell lines, stably transduced with an MYBL2 shRNA (Figure 2B). The gene discussed is MYBL2; the disease is posterior cortical atrophy.