LATS1 and posterior cortical atrophy: In addition, the results of in vitro experiments indicated that silencing of LATS1 or transduction of mutant YAP-S127A (which cannot be inactivated by Hippo kinases) in PCa cells significantly reversed the anti-proliferation and pro-apoptotic effects after RNAi-mediated depletion of MYBL2 in androgen-ablated medium (Figure S2C-D).