The results of the present study extend our understanding of their connection by showing that MYBL2 also affects YAP-TEAD transcriptional activity by regulating the RACGAP1/RhoA/LATS1 kinase cascade, implying a positive feedback mechanism between MYBL2 and YAP signaling in tumor initiation and malignant progression. This evidence concerns the gene RACGAP1 and neoplasm.