FGFR4 and hepatocellular carcinoma: To explore whether FGFR4 was involved in HOXB5-induced HCC metastasis, we knocked down FGFR4 expression in HOXB5-overexpressing cell PLC/PRF/5-HOXB5 and ectopically upregulated FGFR4 expression in MHCC97H-shHOXB5 cells (Figure 2F).