To more broadly assess the expression profiles of L1CAM, CXCR4 and NODAL genes in CRC, we performed a quantitative PCR (qPCR) analysis on PDOx_SC, PDOx_IC, PDOx_LiMets (Figure S2D) and PDOs (Figure S2E). This evidence concerns the gene CXCR4 and colorectal carcinoma.