Since both L1CAM and CXCR4 have been implicated in YAP activation in other cancers 19,20 and YAP is known to enforce CSC phenotype in CRC GEMM (genetically engineered mouse model)21,22 we looked at the relationship between L1CAM and CXCR4 expression with regards to YAP activation in CRC cells. The gene discussed is L1CAM; the disease is cancer.