NFKB1 and hyperuricemia: Previous studies have shown that a Chinese herbal compound containing S. moellendorffii, Smilacis glabrae Rhizoma, and Plantaginis Semen, at a ratio of 3 : 1 : 1, can significantly inhibit the activation of nuclear factor-κB (NF-κB) and the expression of its target genes, interleukin-1β (IL-1β), prostaglandin E2 (PGE2), and IL-8, thereby playing an important role in the prevention and treatment of hyperuricemia and gout [16].