The core targets of Plantaginis Herba for the treatment of hyperuricemia were AKT1, mitogen-activated protein kinase 3 (MAPK3), MAPK1, tumor necrosis factor (TNF), prostaglandin-endoperoxide synthase 2 (PTGS2), sirtuin 1 (SIRT1), estrogen receptor 1 (ESR1), and androgen receptor (AR). This evidence concerns the gene ESR1 and hyperuricemia.