PTGS2, AKT1, IGF1R, TNF, KDR, PYGL, MAPK3, and MAPK1 were the targets that connected with more active ingredients and pathways, suggesting that these targets might be the key targets for the treatment of hyperuricemia with Plantaginis Herba; these results are consistent with the PPI network analysis results in Section 2.3. This evidence concerns the gene TNF and hyperuricemia.