To explore the effect of nine prognostic CCT subunit genes and clinical features, the prognostic-related clinical characteristics in the TCGA database of age, gender, stage, TNM, and CCT subunit genes were analyzed using univariate analysis respectively, which showed that TCP1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT6B, CCT7, CCT8, and stage exhibited significant relationships with prognosis of HCC (all P < 0.05; Supplementary Table 1). This evidence concerns the gene CCT2 and hepatocellular carcinoma.