Interestingly, high expression of TCP1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, and CCT8 was significantly associated with poorer prognosis for HCC patients from the TCGA and ICGC cohorts (all P < 0.01; Figures 2A–H, Figures 3A–I). This evidence concerns the gene CCT5 and hepatocellular carcinoma.