For example, melanoma cell-secreted exosomal miR-155-5p, which was selected as a survival-associated miRNA, could induce a proangiogenic switch of fibroblasts associated with cancer through improving proangiogenic factors' expression in recipient fibroblasts via SOCS1/JAK2/STAT3 signaling pathway (Zhou et al., 2018). The gene discussed is SOCS1; the disease is melanoma.