We first established the regulatory network of TFs-miRNAs-target genes for the recurrence of CRC, involving 29 TFs, 58 miRNAs, and five hub genes, such as models GATA6-MIR106A-CNN1, SP4-MIR424-TPM2, SP4-MIR326-MYL9, HSF1-MIR424-TPM2, ETS1-MIR22-TIMP1, and ETS1-MIR22-SPARCL1. Here, HSF1 is linked to colorectal carcinoma.