However, another oncogene H19 (Guan et al., 2016; Kou et al., 2019) was up-regulated in TP53INP2-high patients, suggesting the potential feedback loop in the HNSCC carcinogenesis of the TP53INP2-high patients regulated by lncRNAs. This evidence concerns the gene TP53INP2 and head and neck squamous cell carcinoma.