Either HLA-DQ2.5 (encoded by the HLA-DQA allele, HLA-DQA1*05 and HLA-DQB allele HLA-DQB1*02), HLA-DQ2.2 (HLA-DQA1*02 and HLA-DQB1*02 alleles), or HLA-DQ8 (HLA-DQA1*03 and HLA-DQB1*03:02 alleles) are present in almost all patients with CeD (31). The gene discussed is HLA-DQB1; the disease is cranioectodermal dysplasia.