Four of the enriched target genes have been reported to be associated with autoimmune diseases in the GWAS catalogue, i.e. IL-6 (juvenile idiopathic arthritis), PRDM1 (systemic lupus erythematosus, inflammatory bowel disease), IL-13 (psoriasis, inflammatory bowel disease), and TLR4 (inflammatory bowel disease). The gene discussed is TLR4; the disease is autoimmune disease.