In peripheral blood CD19+ B cells of newly-diagnosed patients with type 1 diabetes, systemic lupus erythematosus and autoimmune thyroid disease reduced levels of PTEN and increased expression of PTEN regulating miRNAs (miR-21-3p, miR-22-3p and miR-7-5p) have been reported (56, 57). The gene discussed is PTEN; the disease is autoimmune thyroid disease.