Furthermore, our miRNA-target enrichment analysis revealed several enriched target genes with known roles either in B cell function or RA pathogenesis, among them IL-6, IL-13 and STAT3. IL-6 is a highly abundant inflammatory cytokine in RA, and our observed reduction in expression of miRNAs from the let-7 family could potentially be involved in upregulating the IL-6 translation. This evidence concerns the gene STAT3 and rheumatoid arthritis.