The importance of Foxp3 has been illustrated by studies of Foxp3 gene mutations, immune dysregulation, polyendocrinopathy, enteropathy, and X-linked (IPEX) syndrome in humans, and Scurfy mutant mice bearing Foxp3 mutations develop lethal multi-organ autoimmunity (27–30). The gene discussed is FOXP3; the disease is Abnormal intestine morphology.