Besides, the GBP5 gene has been studied in a variety of cancers, including gastric adenocarcinoma (54), skin cutaneous melanoma (55, 56), pancreatic adenocarcinoma (57), and HCC, and GBP5 was one of the key genes in the malignant transformation induced by microcystin-LR (MC-LR) in the cell of HCC (58). The gene discussed is GBP5; the disease is pancreatic adenocarcinoma.