On the contrary, the highest basal TSG-6 levels in the whole blood supernatants were measured in the plasma samples of patients with RA in the remission form of the disease; the basal level of TSG-6 showed a median of 400 pg/ml, which was induced to 1,800 pg/ml by SA1, and was further increased significantly by 500 μm SZR72 to 4,500 pg/ml (Figure 5). Here, TNFAIP6 is linked to rheumatoid arthritis.