This is the first complex study to investigate the effects of KYNA analog, SZR72 on the in vitro production of TNF-α, TSG-6, and the calgranulins as calprotectin and EN-RAGE, together with HNP1–3 (defensin-α) in patients with RA in various activities of the disease. This evidence concerns the gene TNFAIP6 and rheumatoid arthritis.