Next, we compared the levels of RBD- and N- reactive IgM, IgG and IgA from our cohort of acute COVID-19 subjects, and found general trends showing higher antibody levels with more days of symptoms, with N-specific IgA significantly correlating with symptom length; however, some subjects have pre-pandemic levels of RBD- and/or N- reactive IgG, even after as long as 40 days of symptoms (Figures 5D, E). The gene discussed is CD40LG; the disease is COVID-19.