Likewise, ULPBs (i.e., ULBP2/5/6 and 3) were upregulated at the mRNA level upon infection with some strains— ULBP2/5/6: Merlin, P4, P14, P15 at 24 hpi, and Merlin and P15 at 48 hpi; ULBP3: P4, P6, and P10 at 24 hpi, and Merlin and P4 at 48 hpi—, but their cell surface expression has been mostly downregulated or unaffected in comparison with mock-infected cells (Supplementary Figures 2B, C). The gene discussed is ULBP2; the disease is infection.