FASLG and Alzheimer disease: Furthermore, activation of Th17 cells in AD patients has been demonstrated by Saresella et al. (68) and Th17 cells, which infiltrated into AD brain parenchyma, participate in neuroinflammation and neurodegeneration of AD by release of proinflammatory cytokines and by direct action on neurons via the Fas/FasL apoptotic pathway (67).