MTOR and neoplasm: The purposes of our study were to: (1) Clinically characterize nonfunctional PNETs in a large population of patients with TSC, (2) Evaluate the impact of mTOR inhibitors on tumor growth, and (3) Review medical management reported in our case series, in conjunction with the reports in the medical literature, to summarize the current management and treatment regimens for nonfunctional PNETs.