We have shown that atherosclerosis can be promoted by IHC in the PA trunk and its proximal branches of both ApoE−/− and Ldlr−/− mice (Douglas et al., 2013; Xue et al., 2017; Imamura et al., 2019), demonstrating that the effect of IHC on the PA is not genetic background-dependent. Here, APOE is linked to atherosclerosis.