Supporting the anti-inflammatory role of FFAR2, in 2013 Masui et al. showed that DSS-induced colitis was exacerbated in FFAR2 KO mice through the increase in proinflammatory cytokines, such as TNF-α and IL-17, and through the decrease in anti-inflammatory cytokine IL-10 in the colonic mucosa. The gene discussed is FFAR2; the disease is colitis.