Following anthracyclines and cyclophosphamide treatment, the human epidermal growth factor receptor 2 (HER2; ErbB2)/neu inhibitor trastuzumab (Trz), in combination with paclitaxel, improves outcomes in women with surgically removed HER2-positive breast cancer (Romond et al., 2005). The gene discussed is ERBB2; the disease is breast carcinoma.