FMO5 and endothelial dysfunction: In addition, salusin-β causes endothelial dysfunction and injury in diabetes mellitus (Sun et al., 2017; Zhao et al., 2017) and provokes the NAD(P)H oxidase derived-reactive oxygen species (ROS) production in human umbilical vein ECs (Panieri and Santoro, 2015; Sag et al., 2017; Yin et al., 2017; Esfahani et al., 2018).