REN and hypertensive disorder: This local modulation of Ang II responses may be even more necessary in 2K1C animals, which is a hypertension model that has activation of the renin-angiotensin-aldosterone system due to increased renin secretion by the clipped kidney leading to increases in circulating renin and ANG II levels (Martinez-Maldonado, 1991; Ceron et al., 2010).