From this point of view, what JAC shows in UC patients after anti-TNF treatment is in line with similar modifications already described in rheumatoid arthritis (Pasek et al., 2006; Croce et al., 2007; Van Beneden et al., 2009; Stümer et al., 2017), suggesting a not disease-specific pathway of anti-TNF in restoring fully glycosylated moiety. Here, TNF is linked to rheumatoid arthritis.