Notably, age, sex, leukocytes, cohort, high-risk cytogenetics, FLT3 ITD, and NPM1 mutations were not significantly associated with high c-Myc-immunopositivity in univariate and multivariate analyses, suggesting that c-Myc protein expression is independent of most clinical features of AML (Table 3). The gene discussed is NPM1; the disease is acute myeloid leukemia.