FLT3 and acute myeloid leukemia: Notably, age, sex, leukocytes, cohort, high-risk cytogenetics, FLT3 ITD, and NPM1 mutations were not significantly associated with high c-Myc-immunopositivity in univariate and multivariate analyses, suggesting that c-Myc protein expression is independent of most clinical features of AML (Table 3).