Another study on the effects of Wogonin on the proliferation and invasion of U87 glioma cells and its related mechanisms showed that Wogonin has the ability to inhibit U87 cell proliferation and invasion, decrease ezrin protein Bcl-2 and phosphorylated ezrin protein levels, and significantly increase Bax protein expression and the apoptosis index. This evidence concerns the gene BCL2 and central nervous system cancer.