TLR4 and inherited lipid metabolism disorder: Dyslipidaemia can enhance the CXCR3+ follicular T helper cell (TFH cell) response and promote immunoglobulin IgG2c production in a manner dependent on Toll-like receptor 4 (TLR4) and the cytokine IL-27 in the SLE mouse model (Ryu and Chung, 2018; Ryu et al., 2018).