PGD2 could aggravate SLE disease by promoting basophil accumulation in the lymph nodes through interactions with the CXCL12-CXCR4 axis, and antagonize PGD2 receptors (PTGDR) can reduce lupus-like disease in induced and spontaneous mouse models (Pellefigues et al., 2018), PGD2/PTGDR axis maybe a ready-to-use therapeutic target in SLE. This evidence concerns the gene CXCL12 and systemic lupus erythematosus.