In addition, downregulated adipogenic markers (Wu et al., 2009; Marangoni et al., 2015) peroxisome proliferator activated receptor-γ2 (PPARγ2), fatty acid-binding protein 4 (FABP4) and adiponectin) as well as reduced thickness and total volume of dermal white adipose tissue (dWAT) (Kasza et al., 2016) were detected in skin from scleroderma mouse models. This evidence concerns the gene FABP4 and scleroderma.