KCNK3 and atrial fibrillation: In contrast to AF patients, a downregulation of TASK-1 has been observed in patients with severe impairment of left ventricular function, leading to the assumption that a therapy with TASK-1 inhibitors would have a smaller effect on patients with paroxysmal AF and severely impaired left ventricular function compared to patients with a normal left ventricular function (Schmidt et al., 2015, 2017).