KCNK3 and atrial fibrillation: Furthermore, it was shown that atrial tissue undergoes an electrical remodeling process during AF—indicating an atrial cardiomyopathy—that leads to a strong upregulation of TASK-1 mRNA and protein levels, which are observed on a functional level as well (Barth et al., 2005; Schotten et al., 2011; Schmidt et al., 2015).