Extracts or active ingredients of TCMs show anti-AD effects via multiple mechanisms, such as improving acetylcholine levels and decreasing acetyl cholinesterase activity (Wang et al., 2018), suppressing abnormal phosphorylation of Tau protein (Ma et al., 2019), inhibiting neuronal apoptosis (Wang et al., 2019; Zhang et al., 2019), anti-oxidation (Tong et al., 2018), anti-inflammation (Maione et al., 2018), and inhibiting Aβ42 deposition (Shi et al., 2018; Zhang et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.