MAPT and Alzheimer disease: In the perspective of modern medicine, TCM extracts and their active ingredients have been proved to exhibit anti-AD effects through improving acetylcholine level and decreasing acetyl cholinesterase activity (Wang et al., 2018), suppressing abnormal phosphorylation of Tau protein (Ma et al., 2015), inhibiting neuronal apoptosis (Ji et al., 2020), anti-oxidation (Xu et al., 2017), anti-inflammation (Liu et al., 2014), and inhibiting Aβ deposition (Chiroma et al., 2019) in different studies.