To avoid VEGF overexpression and minimize detrimental effects on liver function, both induced by post-embolization ischemia, the idea of the transient occlusion of tumour feeding arteries (a half-life in vitro of 35–50 min) using DSM was born (Pieper et al., 2015; Schicho et al., 2016). Here, VEGFA is linked to neoplasm.