KLHL members associated with inherited forms of the human disease include KLHL3, KLHL7, KLHL9, KLHL12, and GAN (KLHL16), whereas KLHL6, KEAP1 (KLHL19), KLHL20, and ENC1 (KLHL37) are associated with cancer (Dhanoa et al., 2013). This evidence concerns the gene ENC1 and cancer.