Although research has demonstrated that NRG1 can promote axonal regeneration and play a neuroprotective role in neurodegenerative diseases (Ryu et al., 2012; Mancuso et al., 2016; Xu et al., 2016), it remains unclear about the biological functions and related mechanisms of NRG2 in neurodegenerative diseases, especially in AD. Here, NRG1 is linked to Alzheimer disease.