In another 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxin-based mouse model of PD, researchers also found that systematic administration of NRG1β1-ECD can rescue nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase (Depboylu et al., 2015). This evidence concerns the gene ERBB4 and Parkinson disease.