Using an independent family-based sample, scientists found one SNP rs11192423 associated with AAO both in the case-control sample (p = 0.0155) and in the family sample (p = 0.0166), indicating that genetic variants in the NRG3 gene play a role in AD and SNPs in the NRG3 genes and were more strongly associated with AAO of AD (Wang K.-S. This evidence concerns the gene NRG3 and Alzheimer disease.