To date, numerous pathogenic gene variants in the PI3K-mTOR pathway and GATOR1 complex have been identified as genetic causes leading to mTORC1 hyperactivity, MCD, and epilepsy, and more will undoubtfully emerge with increasing accessibility to advanced genomic tools (Marsan and Baulac, 2018; Muhlebner et al., 2019). Here, MTOR is linked to epilepsy.