This also suggests that MLR glutamatergic neurons (and especially CnF glutamatergic neurons, Chang et al., 2020) are a relevant target to improve navigation adaptable to the environment in conditions where locomotion is impaired such as Parkinson’s disease (Plaha and Gill, 2005; Hamani et al., 2016a, b; Goetz et al., 2019), spinal cord injury (Bachmann et al., 2013; Richardson, 2014; Roussel et al., 2019; for review Chari et al., 2017) and stroke (Fluri et al., 2017). This evidence concerns the gene NPHS1 and Parkinson disease.