In a photothrombotic stroke model, Hv1 KO mice displayed smaller brain infarction and fewer motor coordination deficits compared to the WT group during the first three days after injury (Tian et al., 2016), in part by reducing the pro-inflammatory (M1)- and increasing the anti-inflammatory (M2)-type polarization of microglia and macrophages (Tian et al., 2016). The gene discussed is HVCN1; the disease is Stroke.