CD209 and infection: As for the WNV, DC-SIGN/L-SIGN receptors are essential for optimal entry and infection by various ZIKV strains, and the glycan-binding domains and glycosylation of ZIKV E protein might play a role in the viral pathogenesis of different strains (Fernando et al., 2016; Carbaugh et al., 2019; Routhu et al., 2019).